Study of relationship between serum creatine phosphokinase levels with severity of alcohol withdrawal

Rani Malik; Harpreet Singh Dhillon; Vinod Kumar Sahu; Shibu Sasidharan; Gurpreet Kaur Dhillon

doi:10.4103/AMH.AMH_4_21

Previously Andhra Pradesh Journal of Psychological Medicine
ISSN 2249-5851

Users Online: 692

ORIGINAL ARTICLE

Year : 2021 \| Volume : 22 \| Issue : 1 \| Page : 63-67

Study of relationship between serum creatine phosphokinase levels with severity of alcohol withdrawal Rani Malik¹, Harpreet Singh Dhillon², Vinod Kumar Sahu³, Shibu Sasidharan⁴, Gurpreet Kaur Dhillon⁵ ¹ Assistant Professor, Department of Psychiatry, Naval Hospital, Vishakhapatnam, Andhra Pradesh, India ² Assistant Professor, Department of Psychiatry, IFH Level III Hospital MONUSCO, Goma, DRC ³ Assistant Professor Psychiatry, People's College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India ⁴ Assistant Professor, Department of Anaesthesiology and Critical Care, IFH Level III Hospital MONUSCO, Goma, DRC ⁵ Assistant Professor, Department of Paediatrics, Military Hospital, Jammu, India Correspondence Address: Dr. Harpreet Singh Dhillon Department of Psychiatry, Level III Hospital, Goma DRC Source of Support: None, Conflict of Interest: None DOI: 10.4103/AMH.AMH_4_21

Background: Alcohol withdrawal syndrome is a potentially life-threatening condition with severe complications such as withdrawal seizures and delirium tremens. A valid and reliable biomarker for predicting the severity of alcohol withdrawal can be instrumental in individualizing effective therapy at the earliest. Methodology: This was an observational study done on 120 patients to study the relationship between serum creatine phosphokinase (CPK) levels with severity of alcohol withdrawal. The assessment for the severity of alcohol withdrawal was done with Clinical Institute Withdrawal Assessment for Alcohol-revised (CIWA-Ar) scale and an association was studied between the serum CPK levels and the severity of alcohol withdrawal. The data was analyzed using Chi-square test and Kruskal–Wallis tests. Results: The severity of alcohol withdrawal as per the CIWA was 26.66% mild, 55% moderate, and 18.33% severe. The mean serum CPK level for mild withdrawal was 126.93 IU/L, moderate withdrawal was 303.66 IU/L, and for severe withdrawal was 780.81 IU/L. A statistically significant association was obtained indicating that patients with higher CIWA-Ar scores are likely to have a higher level of serum CPK levels. Conclusion: Serum CPK levels were significantly associated with severity of alcohol withdrawal and can possibly serve as a candidate biomarker.



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