• Users Online: 142
  • Print this page
  • Email this page
Year : 2022  |  Volume : 23  |  Issue : 1  |  Page : 56-61

Correlation between Clinical Dementia Rating and brain neuroimaging metrics of Alzheimer's disease: An observational study from a tertiary care institute of Eastern India

1 Associate Professor, Department of Radiodiagnosis, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India
2 Assistant Professor, Department of Radiology, ICARE Institute of Medical Sciences and Research and Dr. Bidhan Chandra Roy Hospital, Haldia, West Bengal, India
3 Tutor Demonstrator, Department Community Medicine, Deben Mahata Government Medical College and Hospital, Purulia, West Bengal, India
4 Research Fellow, Department of Computer Science Engineering, Maulana Abul Kalam Azad University of Technology, Kolkata, West Bengal, India

Correspondence Address:
Dr. Arkaprabha Sau
Professor Colony, Panskura R.S, Purba Medinipur - 721 152, West Bengal
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/amh.amh_87_21

Rights and Permissions

Context: Dementia is an already established major clinical health problem globally as well as in India. Neuroimaging, particularly magnetic resonance imaging (MRI), has an established role to support a clinical diagnosis of Alzheimer's disease (AD) by identifying certain brain atrophy patterns. Aims: The aim of this study was to assess clinico-radiological utility of neuroimaging biomarkers of AD. Settings and Design: This was an observational study with cross-sectional design with 36 patients of AD in a tertiary care hospital in Eastern India. Materials and Methods: Patients with AD in the age group of 55–90 years were subjected to MRI brain examination as per protocol at the Department of Radiodiagnosis, IPGMER and SSKM Hospital, Kolkata. The GCA (Global Cortical Atrophy) score, mesial temporal atrophy (MTA) score, Fazekas grading score, and Koedam score were determined and these MRI parameters were correlated statistically with Clinical Dementia Rating (CDR) score for further analysis. Statistical Analysis Used: IBM SPSS Statistics Version 20 was used as a statistical tool, and Spearman's rho coefficient was used as statistical test for correlation, and P < 0.05 was considered as statistically significant. Results: Average hippocampal volumes showed a significant negative correlation with CDR depicting a clinical deterioration, can be used as probable marker of brain atrophy. This is reinforced by the findings of significant positive correlations of CDR with GCA, MTA, and Koedam's score. Conclusions: It is proposed that global cortical atrophy, MTA, and Koedam score can be used as a basic screening imaging biomarker of AD in the population with dementia.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded31    
    Comments [Add]    

Recommend this journal