Year : 2015 | Volume
: 16 | Issue : 2 | Page : 148--150
Aripiprazole induced priapism: A case report
Satya K Trivedi1, Ajish G Mangot2, Siddhartha Sinha3
1 Senior Resident in psychiatry, Department of Psychiatry, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal, Madhya Pradesh, India
2 Assistant professor of Psychiatry, Department of Psychiatry, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal, Madhya Pradesh, India
3 Senior Resident in psychiatry, Department of psychiatry, Ranchi Institute of Neuro-Psychiatry and Allied Health Sciences (RINPAS), Kanke, Ranchi, Jharkhand, India
Background: Priapism is a urologic emergency representing a true disorder of penile erection that persists beyond or is unrelated to sexual interest or stimulation. Variety of drugs is known to produce priapism, including psychotropics.
Case description: We report a case of an adolescent young male with psychosis who developed priapism after taking a single oral dose of 10mg aripiprazole.
Discussion: Virtually all antipsychotics have been known to be rarely associated with priapism. The potential of antipsychotics to cause priapism is believed to be dependent on their affinity to block alpha-1 adrenergic receptors. Aripiprazole has the least affinity to adrenergic receptors among all atypical antipsychotics. This makes it an extremely rare occurrence all around the world.
Conclusion: Polymorphism of alpha-2A adrenergic receptor gene in schizophrenia patients is known to be associated with sialorrhoea while on clozapine treatment. Probably similar polymorphism of alpha-1 adrenergic receptor gene could contribute to its altered sensitivity and resultant priapism.
Satya K Trivedi
Senior Resident, Department of Psychiatry, People's College of Medical Sciences and Research Centre, Bhanpur, Bhopal, Madhya Pradesh
|How to cite this article:|
Trivedi SK, Mangot AG, Sinha S. Aripiprazole induced priapism: A case report.Arch Ment Health 2015;16:148-150
|How to cite this URL:|
Trivedi SK, Mangot AG, Sinha S. Aripiprazole induced priapism: A case report. Arch Ment Health [serial online] 2015 [cited 2022 May 23 ];16:148-150
Available from: https://www.amhonline.org/article.asp?issn=2589-9171;year=2015;volume=16;issue=2;spage=148;epage=150;aulast=Trivedi;type=0